Summary
Alignment of neurons represented as sequences of branching points can be used to detect clusters of similar neurons which can then be investigated for their stereotypical branching patterns. We use a modified sequence alignment procedure to produce pairwise similarity values between two neuronal sequences and then, after embedding the neurites (axons, dendrites, or apical dendrites) into a consistent abstract space, we found clusters in the space. By overlaying those clusters with known cell classes we found significant associations. There were strong associations by cell type, brain region, and species, indicating that neuronal branching patterns are indicative of neuronal type and function.
